Table 1.
Spontaneous tumorigenesis of Ovca 1-2+/− mice in p53+/+, p53+/−, and p53−/− backgrounds in comparison to p53+/− and p53−/− mice
| Ovca 1-2+/− | Ovca 1-2+/−p53+/− | Ovca 1-2+/−p53−/− | p53+/− | p53−/− | |
|---|---|---|---|---|---|
| Total number | 44 | 25 | 31 | 22 | 31 |
| Male | 29 | 6 | 15 | 6 | 21 |
| Female | 15 | 19 | 16 | 16 | 10 |
| Tumor incidence (%) | 25 (56.8) | 18 (72) | 31 (100) | 11 (50.0) | 31 (100) |
| Tumor spectrum (%) | |||||
| Lymphoma | 12 (40) | 9 (50.0) | 23 (62.2) | 4 (36.4) | 25 (80.6) |
| Osteosarcoma | 0 | 2 (11.1) | 0 | 6 (54.5) | 0 |
| Soft tissue sarcomaa | 3 (10) | 2 (11.1) | 11 (33.3) | 1 (9.1) | 4 (12.9) |
| Adenoma/carcinomab | 15 (50) | 5 (27.8) | 1 (3.03) | 0 | 2 (6.5) |
| Teratoma | 0 | 0 | 1 (3.03) | 0 | 1 (3.2) |
| Brain tumor | 0 | 0 | 1 (3.03) | 0 | 0 |
| Total tumor number | 30c | 18 | 37d | 11 | 32e |
| Mean latency (weeks) | 92 | 52 | 21 | 70 | 20 |
The tumor-free survival of wild-type mice included two females and four males that were age-matched B6129 mixed genetic background sampled from our colony (n > 500).
Soft tissue sarcomas include fibrosarcoma, malignant histiocytoma, and hemangioma/hemangiosarcoma.
All types of epithelium-derived tumors are included. One pulmonary adenoma with increased mitotic figures was found in an Ovca 1-2+/− p53−/− mouse. Two p53−/− mice were found with adenomatous polyp (adenoma) in the intestine and adenoma in the lung, respectively. Two mammary gland adenosquamous carcinomas, two lung adenocarcinomas, and one keratinized squamous tumor (keratoacanthoma) were identified in Ovca 1-2+/− p53+/− animals (5/18). Adenoma or carcinoma in liver (n = 4) and lung (n = 10) were the major epithelial tumors of Ovca 1-2+/− mice. One ovarian cystadenoma was found in an Ovca 1-2+/− female.
Five mice were found with multiple tumor burden. Two mice were found with hepatoma and lung adenoma. One mouse had a lung adenoma nd a malignant stromal tumor. One mouse developed lung adenoma and lymphoma. One mouse had a lung adenoma and ovarian cystadenoma.
Six mice were found with multiple tumor burden. Five mice were found with lymphoma and soft tissue sarcomas. One mouse had three types of neoplasms, including lymphoma, hemangioma, and adenoma.
One p53−/− mouse had lymphoma and lung adenoma.