TABLE 2.
UGT1A9 Clearance | ||||
---|---|---|---|---|
Parameter | Well Stirred |
Parallel Tube |
||
Allometric | Simcyp | Allometric | Simcyp | |
Normalized adult clearance | 1.1 | 1.2 | ||
r2 | 0.7 | 0.8 | ||
95% CI of adult clearance | 1.0, 1.3 | Did not converge | 1.1, 1.4 | Did not converge |
Age at adult activity | 17.9 yr | 19.5 yr | ||
Absolute sum of squares | 4.8 | 4.4 | ||
Sy.x | 0.19 | 0.18 |