TABLE 3.

Summary of chemical- and transcription factor-dependent mRNA changes

Increases in mRNA expression are denoted as <3-fold (↑), 3- to 30-fold (↑↑), and >30-fold (↑↑↑). Reductions in mRNA expression are denoted as levels decreased to >75% of control (↓), 50 to 75% of control (↓↓), and <50% of control (↓↓↓).

Genes	AhR		CAR		PXR		PPARα		Nrf2
	♂	♀	♂	♀	♂	♀	♂	♀	♂	♀
Phase I enzymes
Cyp1a2	↑↑	↑	↑	↑					↑	↑
Cyp2b10	↑↑		↑↑↑	↑↑↑		↑↑
Cyp3a11			↑↑	↑	↑	↑	↑			↑
Cyp4a11				↓↓↓			↑↑↑	↑↑		↑↑
Nqo1	↑↑	↑↑	↑				↑↑		↑↑	↑↑
Aldh1a1			↑	↑		↑↑	↑	↑	↑	↑
Aldh1a7		↑	↑	↑↑		↑	↑			↑
Aldh1b1
Aldh3a2	↓↓↓						↑
Aldh4a1				↓
Aldh6a1				↓↓
Aldh7a1	↑	↑		↓
Aldh9a1							↑
Phase II enzymes
Ugt1a1	↑	↑	↑	↑	↑	↑
Ugt1a5					↑	↑	↑
Ugt1a6	↑	↑↑								↑
Ugt1a9	↑↑	↑↑	↑		↑	↑↑	↑
Ugt2a3	↓↓		↓↓	↓↓						↓↓
Ugt2b1	↓↓↓						↓↓↓
Ugt2b34		↑	↑	↑		↑				↑
Ugt2b35	↑	↑	↑↑
Ugt2b36			↑						↑
Sult1e1			↑↑↑	↑↑
Sult2a2				↑		↑↑
Sult3a1		↓↓↓	↑↑↑	↑↑						↑
Sult5a1	↑	↑↑	↑	↑				↓↓
Papss2		↓↓	↑	↑		↑	↑
Gsta1		↑↑	↑↑	↑↑	↑↑	↑↑↑	↑↑		↑↑	↑↑↑
Gsta4		↑	↑	↑		↑			↑	↑
Gstt1	↓↓		↑	↑
Gstt2		↑					↑
mGst3							↑↑	↑	↑	↑
Gstm1		↑	↑↑	↑	↑	↑↑	↑		↑↑	↑
Gstm2		↑	↑↑	↑↑	↑	↑↑			↑↑	↑↑
Gstm3	↑	↑↑	↑↑	↑↑	↑↑	↑↑↑	↑		↑↑	↑↑
Gstm4			↑	↑		↑	↑	↑	↑↑	↑↑
Transporters
Oatp1a1	↓↓↓	↓↓↓	↓↓↓			↓↓				↓↓↓
Oatp1a4			↑		↑↑	↑↑
Mate1							↑
Mrp2		↑	↑	↑		↑	↑
Mrp3		↑	↑↑	↑	↑	↑↑	↑		↑	↑↑
Mrp4	↑	↑↑	↑↑	↑↑			↑	↑	↑↑	↑↑
Abcg5							↑