Figure 1. Expression of human MUC1 accelerates colonic inflammation and dysplasia in DSS-treated mice. (A) Human MUC1.tg mice (black) and Wt mice (gray) were given two cycles of DSS in drinking water and body weight was monitored over time. (B) After two cycles of DSS, MUC1.tg and Wt mice were sacrificed, colons removed and paraffin embedded, and stained with H&E. H&E stained colon sections were examined by pathologist and given inflammation scores (see Materials and Methods) and assessed for dysplasia. p was determined by two-tailed unpaired t-test. (C) Representative H&E stained colon sections showing high-grade dysplasia in MUC1.tg and no dysplasia in Wt mice. Scale bars are 100 µm.