Figure 3. Precise oncoantigen classification (A). Validated class I, II and III oncoantigens present in various tumor compartments currently targeted by our therapeutic vaccines (B). Comp,⁵³ (black ♌) and Angiomotin 1,⁵⁴ (red Y) are validated class I oncoantigens expressed on tumor extracellular matrix and on tumor vasculature respectively (left panel). ErbB-2,⁵⁵ (blue Y), Epsin, (brown E), Claudin,⁵³ (green C) and CSPG4,⁵⁶ (purple f) are class II oncoantigens expressed on tumor cell membrane (middle panel). The protein product of the NPM-ALK translocation,⁵⁷ (ALK, purple ♒) and BIRC5,⁵³ (orange b) are class III oncoantigens present in the cytoplasm and nucleus of carcinomas and lymphomas (right panel). Several additional molecule endowed with the properties of oncoantigens have been validated in immunization assay by other laboratories.⁵⁸