Table 4. Binding kinetics of chimeric and humanized 3F8 by surface plasmon resonance.
| Antibody | kon | koff | KD (nM) |
|---|---|---|---|
| ch3F8-IgG1 |
1.15E + 05 |
1.45E − 03 |
13 ± 3 |
| hu3F8-IgG1 |
9.19E + 04 |
1.03E − 03 |
11 ± 1 |
| ch3F8-IgG4 |
9.40E + 04 |
1.28E − 03 |
14 ± 2 |
| hu3F8-IgG4 |
1.18E + 05 |
1.76E − 03 |
15 ± 1 |
| m3F8 |
1.74E + 05 |
8.74E − 04 |
5 ± 1 |
| 14.G2a |
1.50E + 05 |
1.12E − 02 |
77 ± 8 |
| ME36.1 | 1.21E + 05 | 2.79E − 03 | 19 ± 7 |