Table 1. Operational classification of cytokines.
| Family | Subfamily | Members | Ref. |
|---|---|---|---|
| Chemokines |
C subfamily |
XCL1, XCL2 |
2
,
8
|
| CC subfamily |
CCL1, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL19, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28 |
||
| CXC subfamily |
CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL8, CXCL9, CXCL10, CXCL11, CXCL12, CXCL13, CXCL16, PPBP |
||
| CX3C subfamily |
CX3CL1 |
||
| Hematopoietins |
IL6ST - shared |
CLCF1, CNTF, CTF1, IL-11, IL-6, LIF, OSM |
17
,
18
|
| IL13RA1 - shared |
IL-4, IL-13 |
||
| IL12RB1 - shared |
IL12A, IL23A |
||
| IL3RB1 - shared |
GM-CSF, IL-3, IL-5 |
||
| ILRG - shared |
IL-2, IL-4, IL-7, IL-9, IL-15, IL-21 |
||
| Others |
G-CSF, EPO, GH1, GH2, LEP, PRL, TSLP, TPO |
||
| IL-1s |
|
IL-1A, IL-1B, IL-18 |
43
|
| IL-10s |
|
IL-10, IL-19, IL-20, IL-22, IL-24, IL-28A, IL-28B, IL-29 |
61
|
| IL-17s |
|
IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F |
73
|
| IFNs |
|
IFNα1, IFNα2, IFNβ1, IFNε1, IFNγ, IFNκ, IFNω |
81
-
83
|
| PDGFs |
|
M-CSF, EGF, FLT3L, HGF, KITL, PLEKHQ1, PGDFA-D, VEGFA-D |
89
,
90
|
| TGFβs |
|
AMH, BMP2, BMP7, GDF5, INHBA, INHBB, INHBC, INHBE, TGFβ1, TGFβ2, TGFβ3 |
103
-
106
,
108
|
| TNFs | CD40L, EDA, FASL, LTA, LTB, RANKL, OX40L, TNF, TNFSF7, TNFSF8, TNFSF9, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF18, TRAIL |
111 - 113 |
Abbreviations: AMH, anti-Mullerian hormone; BMP, bone morphogenetic protein; CD40L, CD40 ligand; CLC, cardiotrophin-like cytokine factor; CNTF, ciliary neurotrophic factor; CTF, cardiotrophin; EDA, ectodysplasin A; EGF, epidermal growth factor, EPO, erythropoietin; FASL, FAS ligand; FLT3L, FLT3 ligand; GDF, growth differentiation factor preproprotein; GH, growth hormone; G-CSF, granulocyte colony stimulating factor; GM-CSF, granulocyte macrophage colony stimulating factor; HGF, hepatocyte growth factor isoform; IFN, interferon; IL, interleukin; INHB, inhibin β; INHBE, activin β E; KITL, KIT ligand; LEP, leptin; LIF, leukemia inhibitory factor; LT, lymphotoxin; M-CSF, macrophage colony stimulating factor; OSM, oncostatin M, OX40L, OX40 ligand; PDGF, platelet-derived growth factor; PLEKHQ, PH domain-containing protein; PPBP, pro-platelet basic protein; PRL, prolactin; RANKL, RANK ligand; TGFβ, transforming growth factor β, TNF, tumor necrosis factor; TPO, thrombopoietin; TSLP, thymic stromal lymphopoietin, VEGF, vascular endothelial growth factor.