TABLE 2.
Table of Patient Characteristics (All Enrolled Infants Who Were Evaluated for Death/NDI) That Are Significantly Different by Unadjusted Analysis in Survivors Without NDI, in Comparison With Infants Who Die or Develop NDI
| Variable | Overall | Survivors Without NDI | NDI and/or Death | P (for Survivors Without NDI vs NDI/Death) |
|---|---|---|---|---|
| Day 1 variables | n = 13 085 | n = 4991 | n = 7089 | |
| Birth weight, mean ± SD | 738 ± 156 | 808 ± 130 | 681 ± 151 | <.0001 |
| Gestational age, mean ± SD | 25.5 ± 2 | 26.4 ± 1.9 | 24.8 ± 1.9 | <.0001 |
| SGA, % | 15.2 | 16.5 | 13.5 | <.0001 |
| Male gender, % | 50.2 | 41.9 | 56.5 | <.0001 |
| Black race, % | 42.6 | 40.4 | 44.5 | <.0001 |
| Antenatal steroids, % | 73.1 | 84 | 64.6 | <.0001 |
| Hypertension/PIH, % | 23.4 | 29.8 | 18.1 | <.0001 |
| Outborn, % | 11.9 | 8.5 | 13.9 | <.0001 |
| Cesarean delivery, % | 57.3 | 65.7 | 50.5 | <.0001 |
| Surfactants, % | 84 | 77.2 | 90.8 | <.0001 |
| Intubation | 73.6 | 70.7 | 75.5 | <.0001 |
| 1-min Apgar (median; 25–75th) | 4 (2–6) | 5 (3–7) | 3 (1–5) | <.0001 |
| 5-min Apgar (median; 25–75th) | 7 (5–8) | 7 (6–8) | 6 (3–7) | <.0001 |
| IMV, % | 85.4 | 88 | 53.6 | <.0001 |
| Day 7 variables | n = 10 466 | n = 4975 | n = 4499 | |
| Highest Fio2 on day 7, (mean ± SD) | 0.37 ± 0.2 | 0.33 ± 0.16 | 0.43 ± 0.23 | <.0001 |
| No. days on CPAP (to day 7), (mean ± SD) | 1.16 ± 1.8 | 1.52 ± 2 | 0.74 ± 1.54 | <.0001 |
| IVH grade11 (diagnosed by day 7), % | <.0001 | |||
| Grade IV | 3.5 | 1 | 6.5 | |
| Grade III | 2.4 | 1.4 | 3.6 | |
| Grade I–II | 7.4 | 11.9 | 8 | |
| None | 86.7 | 90.7 | 81.8 | |
| Day 28 variables | n = 9353 | n = 4878 | n = 3523 | |
| Highest Fio2 on day 28 | 0.41 ± 0.23 | 0.37 ± 0.20 | 0.49 ± 0.26 | <.0001 |
| No. episodes late-onset culture-negative clinical infection | 0.88 ± 1.16 | 0.65 ± 0.93 | 1.24 ±1.36 | <.0001 |
| No. days parenteral feeding (to day 28) | 22.1 ± 6.6 | 20.8 ± 7 | 24.1 ± 5.2 | <.0001 |
| No. days on CPAP (to day 28) | 5.01 ± 6.8 | 6.04 ± 7.3 | 3.51 ± 5.8 | <.0001 |
| 36 wk variables | n = 7630 | n = 4029 | n = 2828 | |
| BPD: on ventilator or CPAP at 36 wk, % | 26.8 | 17.3 | 41.8 | <.0001 |
| No. days on CV (to 36 wk) | 23.8 ± 21.1 | 18.2 ± 17.8 | 32.4 ± 22.7 | <.0001 |
| No. days on HFV (to 36 wk) | 3.3 ± 7.9 | 2.1 ± 5.9 | 5.3 ± 9.9 | <.0001 |
| U/S: ventricular size enlarged (day 28 to 36 wk), % | 14.2 | 8.3 | 23.3 | <.0001 |
| U/S: PVL or porencephalic cyst (day 28 to 36 wk), % | 5.3 | 2.3 | 9.8 | <.0001 |
P values are from Fisher exact test (2-tailed) for categorical variables and from unadjusted logistic regression for BPD or death for continuous variables. BPD, bronchopulmonary dysplasia; CV, conventional ventilator; HFV, high-frequency ventilator; IMV, intermittent mandatory ventilation; PIH, pregnancy-induced hypertension.