TABLE 5.
Models Using Variables at 28 Days of Age (n = 6241)
| Variable | Time Period When Variable Was Evaluated | AUC c-statistic | % Increase in AUC | OR (95% CI) | P |
|---|---|---|---|---|---|
| Death/NDI | |||||
| Highest Fio2 on day 28 | Day 28 | 0.656 | 1.11 (1.08–1.14) (per 10% increase) | <.0001 | |
| Episodes of late-onset culture-negative clinical infection | Day 28 | 0.680 | 2.4 | 1.25 (1.18–1.32) (per episode) | <.0001 |
| Days parenteral feeding (to day 28) | Day 28 | 0.695 | 1.5 | 1.05 (1.04–1.06) (per 1 d more) | <.0001 |
| Days on CPAP (to day 28) | Day 28 | 0.707 | 1.2 | 0.97 (0.96–0.98) (per 1 d more) | <.0001 |
| Male gender | Birth | 0.714 | 0.7 | 1.69 (1.50–1.91) | <.0001 |
| Birth weight, g | Birth | 0.721 | 0.7 | 0.83 (0.79–0.87) (per 100-g increase) | <.0001 |
| Death before discharge | |||||
| Highest Fio2 on day 28 | Day 28 | 0.751 | 1.24 (1.20–1.29) | <.0001 | |
| Episodes of late-onset culture-negative clinical infection | Day 28 | 0.776 | 2.5 | 1.22 (1.14–1.31) | <.0001 |
| Birth weight, g | Birth | 0.794 | 1.8 | 0.81 (0.75–0.87) | <.0001 |
| Days parenteral feeding (to day 28) | Day 28 | 0.803 | 0.9 | 1.10 (1.07–1.13) | <.0001 |
| Days on CPAP (to day 28) | Day 28 | 0.809 | 0.6 | 0.95 (0.92–0.97) | <.0001 |
| NDI in survivors | |||||
| Episodes of late-onset culture-negative clinical infection | Day 28 | 0.610 | 1.28 (1.21–1.36) | <.0001 | |
| Days on CV (to 28 days) | Day 28 | 0.652 | 4.2 | 1.04 (1.03–1.04) (per 1 d more) | <.0001 |
| Days on HFV (to 28 days) | Day 28 | 0.678 | 2.6 | 1.07 (1.06–1.09) (per 1 d more) | <.0001 |
| Male gender | Birth | 0.686 | 0.6 | 1.53 (1.35–1.73) | <.0001 |
CV, conventional ventilator; HFV, high-frequency ventilator.