TABLE 6.
Models Using Variables at 36 Weeks Postmenstrual Age (n = 5118)
| Variable | Time Period When Variable Was Evaluated | AUC c-statistic | % Increase in AUC | OR (95% CI) | P |
|---|---|---|---|---|---|
| Death/NDI | |||||
| Days on CV (to 36 wk) | 36 wk | 0.688 | —a | 1.03 (1.02–1.03) (per 1 d more) | <.0001 |
| Days on HFV (to 36 wk) | 36 wk | 0.706 | 1.8 | 1.04 (1.03–1.04) (per 1 d more) | <.0001 |
| U/S: ventricular size enlarged (day 28 to 36 wk) | 36 wk | 0.719 | 1.3 | 1.99 (1.63–2.43) | <.0001 |
| Male gender | Birth | 0.728 | 0.9 | 1.63 (1.43–1.86) | <.0001 |
| U/S: PVL or porencephalic cyst (day 28 to 36 wk) | 36 wk | 0.736 | 0.8 | 3.33 (2.38–4.67) | <.0001 |
| BPD: on ventilator or CPAP at 36 wk | 36 wk | 0.741 | 0.5 | 1.70 (1.44–2.00) | <.0001 |
| Death before discharge | |||||
| Highest Fio2 on 36 wk | 36 wk | 0.855 | —a | 1.30 (1.21–1.40) (per 10% increase) | <.0001 |
| Episodes of late-onset culture-negative clinical infection | Day 28 | 0.873 | 1.8 | 1.28 (1.16–1.42) | <.0001 |
| BPD: on ventilator or CPAP at 36 wk | 36 wk | 0.881 | 0.8 | 3.98 (2.39–6.62) | <.0001 |
| Days on CPAP (to 36 wk) | 36 wk | 0.895 | 1.4 | 0.94 (0.92–0.96) (per 1 d more) | <.0001 |
| Episodes of late-onset sepsis (day 28 to 36 wk) | 36 wk | 0.910 | 1.5 | 1.37 (1.20–1.56) | <.0001 |
| Proven NEC (day 28 to 36 wk) | 36 wk | 0.913 | 0.3 | 2.74 (1.63–4.61) | .0001 |
| Days parenteral feeding (to day 28) | Day 28 | 0.921 | 0.8 | 1.13 (1.06–1.21) | .0002 |
| NDI in survivors | |||||
| Days on CV (to 36 wk) | 36 wk | 0.668 | —a | 1.03 (1.02–1.03) | <.0001 |
| U/S: PVL or porencephalic cyst (day 28 to 36 wk) | 36 wk | 0.685 | 1.7 | 3.28 (2.33–4.61) | <.0001 |
| Days on HFV (to 36 wk) | 36 wk | 0.698 | 1.3 | 1.04 (1.03–1.05) | <.0001 |
| Male gender | Birth | 0.709 | 1.1 | 1.62 (1.42–1.86) | <.0001 |
| U/S:ventricular size enlarged (day 28 to 36 wk) | 36 wk | 0.716 | 0.5 | 1.99 (1.63–2.44) | <.0001 |
BPD, bronchopulmonary dysplasia; CI, confidence interval; CV, conventional ventilator; HFV, high-frequency ventilator; NEC, necrotizing enterocolitis; OR, odds ratio; PVL, periventricular leukomalacia.