Table 2.
Protein | Control average | 1 mM L-NAME average | Change | P |
---|---|---|---|---|
Bad | 50.59 ± 8.08 | 54.73 ± 9.86 | 4.15 | 0.637 |
Bax | 47.65 ± 14.26 | 50.98 ± 13.43 | 3.32 | 0.805 |
Bcl-2 | 31.37 ± 7.47 | 34.32 ± 5.04 | 2.95 | 0.633 |
Bcl-x | 17.62 ± 4.92 | 19.02 ±6.20 | 1.40 | 0.780 |
Pro-Caspase 3 | 107.21 ± 20.89 | 109.96 ± 19.89 | 2.75 | 0.889 |
Cleaved Caspase 3 | 40.89 ± 12.79 | 43.35 ± 6.22 | 2.46 | 0.799 |
Catalase | 93.40 ± 24.75 | 97.04 ± 25.26 | 3.63 | 0.880 |
clAP-1 | 39.80 ± 20.28 | 45.09 ± 20.87 | 5.28 | 0.792 |
clAP-2 | 16.72 ± 4.71 | 18.86 ± 5.27 | 2.15 | 0.630 |
Claspin | 40.49 ± 6.13 | 43.37 ± 6.39 | 2.89 | 0.618 |
Clusterin | 22.70 ± 6.30 | 27.93 ± 7.19 | 5.23 | 0.437 |
Cytochrome c | 68.46 ± 8.61 | 76.39 ± 8.48 | 7.93 | 0.336 |
TRAIL R1/DR4 | 40.74 ± 6.48 | 46.36 ± 3.04 | 5.62 | 0.241 |
TRAIL R2/DR5 | 66.06 ± 16.01 | 77.34 ± 6.60 | 11.28 | 0.363 |
FADD | 64.20 ± 13.56 | 71.59 ± 4.95 | 7.39 | 0.467 |
Fas/TNFSF6 | 66.16 ± 23.27 | 68.26 ± 13.45 | 2.10 | 0.904 |
HIF-1a | 29.40 ± 16.62 | 41.97 ± 15.61 | 12.57 | 0.436 |
HO-1/HMOX1/HSP32 | 27.06 ± 14.68 | 35.64 ± 12.58 | 8.58 | 0.526 |
HO-2/HMOX2 | 38.85 ± 14.23 | 49.90 ± 18.08 | 11.04 | 0.497 |
HSP27 | 33.21 ± 7.16 | 38.64 ± 9.88 | 5.43 | 0.528 |
HSP60 | 65.84 ± 11.85 | 70.83 ± 7.05 | 4.99 | 0.545 |
HSP70 | 66.75 ± 13.76 | 64.40 ± 5.59 | −2.35 | 0.801 |
HTRA2/Omi | 63.09 ± 3.83 | 72.57 ± 4.18 | 9.48 | 0.038* |
Livin | 14.08 ± 2.52 | 18.83 ± 5.12 | 4.75 | 0.223 |
PON2 | 28.81 ± 5.92 | 31.30 ± 5.53 | 2.49 | 0.651 |
p21/CIP1/CDNK1A | 27.93 ± 9.01 | 38.74 ± 9.16 | 10.81 | 0.259 |
p27/Kip1 | 16.75 ± 6.04 | 21.34 ± 2.89 | 4.59 | 0.345 |
Phospho-p53 (S15) | 82.25 ± 19.34 | 88.18 ± 11.03 | 5.93 | 0.696 |
Phospho-p53 (S46) | 64.83 ± 18.94 | 71.42 ± 20.27 | 6.59 | 0.729 |
Phospho-p53 (S392) | 64.02 ± 28.92 | 75.33 ± 22.81 | 11.31 | 0.659 |
Phospho-Rad17 (S635) | 11.71 ± 2.21 | 18.72 ± 5.65 | 7.01 | 0.129 |
SMAC/Diablo | 56.47 ± 11.12 | 59.84 ± 9.98 | 3.36 | 0.742 |
Survivin | 57.52 ± 23.63 | 61.96 ± 19.33 | 4.44 | 0.831 |
TNF RI/TNFRSF1A | 18.18 ± 4.27 | 22.05 ± 1.64 | 3.87 | 0.210 |
XIAP | 49.96 ± 5.39 | 56.28 ± 3.45 | 6.32 | 0.149 |
All values are in percent of the calibrator (positive control). The change is given in percent points of the calibrator. The data were acquired in three independent experiments. *: P < 0.05.