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. 2012 Mar;2(3):120030. doi: 10.1098/rsob.120030

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© 2012 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 5. — The intersection of signalling and transcriptional activity culminates in the suppression of BMP, WNT and Nodal signalling for head formation. Sources of signals in the gastrulation stage embryo: Bone Morphogenetic Protein (BMP) from the extraembryonic ectoderm and the posterior epiblast, and WNT (Wnt2b, Wnt3, Wnt3a and Wnt8a) and Nodal from the posterior epiblast and primitive streak. BMP antagonists Noggin (Nog) and Chordin (Chrd); Nodal antagonist Lefty1; WNT antagonists Dickkorf-1 (Dkk1) and Secreted frizzled-related proteins (Sfrps). Transcription factors: Goosecoid (Gsc), LIM homeobox protein 1 (Lhx1), LIM domain binding 1 (Ldb1), Single-stranded DNA binding protein 1 (Ssdp1); Orthodenticle homologue 2 (Otx2), SRY-box containing gene 17 (Sox17).