Table 2.

Association of Baseline Orthostatic Hypotension with Incident HF, Stratified by Age, Race/Gender and Secondary Analyses with Exclusions; the ARIC study (1987-2008)

Models	N	Incident HF Hazard Ratios	95% Confidence Intervals
Unadjusted	12,363	3.02	(2.59-3.52)
Overall adjusted*	11,743	1.54	(1.30-1.82)
Age-stratified analysis †
Age ≤55 years	6,868	1.90	(1.41-2.55)
Age >55 years	4,875	1.37	(1.12-1.69)
Race and gender stratified analysis †
White Women	4,528	1.59	(1.13-2.23)
African-American Women	1,885	1.60	(1.14-2.24)
White Men	4,155	1.31	(1.00-1.72)
African-American Men	1,175	1.71	(0.98-2.99)
Secondary Analyses with Exclusions
Exclusion of diabetes at baseline†	10,507	1.50	(1.22-1.84)
Exclusion of hypertension at baseline†	7,936	1.34	(1.00-1.80)
Exclusion of individuals on anti- hypertensives (ACE inhibitors, beta- blockers or diuretics) at baseline†	9,111	1.47	(1.17-1.85)
Exclusion of CHD at baseline†	11,329	1.52	(1.27-1.82)
Exclusion of psychiatric or Parkinson’s medications at baseline†	11,017	1.43	(1.19-1.72)
Exclusion of HF cases from first 2 years of follow-up†	11,568	1.60	(1.35, 1.90)

^*Models adjusted for baseline variables: age, gender, race by center, body mass index, educational level, smoking, alcohol use, diabetes mellitus, mean supine systolic blood pressure, resting heart rate, left ventricular hypertrophy, coronary heart disease, and hypertension

^†For secondary analyses, all of the above covariates were adjusted for except the stratified covariates