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. Author manuscript; available in PMC: 2013 Jul 5.
Published in final edited form as: Virology. 2012 Apr 24;428(2):128–135. doi: 10.1016/j.virol.2012.03.006

Figure 2. LigIV homologues.

Figure 2

A. Alignment of the amino acid sequences of the BRCT-1 domains of human, canine, and murine DNA LigIV. Amino acids that diverge from the human sequence are indicated in bold. The four changes present in canine LigIV, also present in mouse and rat (not shown), are indicated by arrows with position in the human protein indicated beneath. B. Canine DNA LigIV is not degraded in adenovirus infection. Extracts of MDCK canine kidney cells infected with adenovirus were fractionated by SDS PAGE and immunoblotted for LigIV, Mre11, p53, and actin. Mre11 and p53 are efficiently degraded, indicating that the viral ubiquitin ligase functions in canine cells, but LigIV is not.