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. Author manuscript; available in PMC: 2013 May 25.
Published in final edited form as: Cell. 2012 May 25;149(5):1035–1047. doi: 10.1016/j.cell.2012.03.046

Figure 3. Details of the SUN-KASH Interaction.

Figure 3

(A) Close-up view of the SUN2-KASH2 interaction. Two neighboring SUN protomers are shown in two shades of blue, with the KASH2 peptides in between in orange. Surface of the SUN2 binding area is half-transparent. KASH residues crucial for interaction are numbered. ‘0’ denotes the C-terminal residue of the peptide. Pocket residues that abolish KASH-binding if mutated are labeled.

(B) Same view of the SUN2-KASH1 interaction. Residues that differ between KASH1 and KASH2 are colored in green.

(C) Multiple sequence alignment of the four identified human KASH proteins, followed by a list of KASH peptides from highly diverged eukaryotes. The numbers match residues important for SUN binding.

See also Figure S3.