Fig. 1.

Plasma concentrations of cocaine produced by intravenous doses of 3 mg/kg cocaine during five biweekly trials in two rhesus monkeys. Plasma cocaine concentrations were assessed by mass spectrometry ∼2 min before cocaine (baseline; BL) and at 8, 15, 30, 60, 90, and 120 min after the administration of cocaine. ○ represent the mean ± S.E.M. plasma concentrations of cocaine when PBS was administered 10 min after 3 mg/kg cocaine. Plasma concentrations of cocaine during the first (▾), second (▿), third (▴), and fourth (▵) trials in which 0.32 mg/kg DM CocE was administered as a post-treatment to 3 mg/kg cocaine are shown. Data from the 8-min time point were excluded because of differences in the post-treatment times (UR, 10 min post-treatment; BE, 1 min post-treatment). Inset shows plasma cocaine concentrations during the four DM CocE conditions plotted on a y axis with a smaller range of concentrations. ***, p < 0.001. Significant differences in plasma cocaine concentrations were determined by two-way ANOVA with repeated measures and post hoc Bonferroni tests.