Fig. 3.

Effects of repeated doses of DM CocE (0.32 mg/kg i.v.) or PBS on the cocaine-induced changes in core body temperature (°C; top) and locomotor activity (bottom) when administered 10 min after an intravenous dose of 3 mg/kg cocaine (n = 3) during six biweekly trials. Left, data points represent the mean ± S.E.M. change from baseline for temperature or sum of locomotor activity over successive 5-min blocks of time during sessions in which 3 mg/kg cocaine was followed by PBS (○) or 0.32 mg/kg DM CocE (triangles). Right, data represent the mean ± S.E.M. change from baseline for temperature or sum of locomotor activity over the entire 110 min after the administration of PBS (filled bars) or 0.32 mg/kg DM CocE (open bars).