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Time course for the development of anti-CocE antibody titers after the repeated administration of 0.32 mg/kg DM CocE. Serum samples were collected 24 h before each of six biweekly trials (PBS and DM CocE) and 4 and 8 weeks after the final DM CocE administration. Symbols represent anti-CocE antibody titers for each of the five monkeys. Solid line represents the mean ± S.E.M. of the anti-CocE antibody titers (n = 5).
