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Competition assays for vemurafenib in MDCKII-MDR1 and MDCKII-Bcrp1 cells by using [3H]vinblastine (VBL) and [3H]prazosin (PRZ) as P-gp and Bcrp prototypical probe substrates, respectively. The addition of increasing concentrations of vemurafenib resulted in an increased accumulation of [3H]prazosin and [3H]vinblastine in Bcrp1 (A) and MDR1 (B) cells, respectively. The data represent mean ± S.D. (n = 3 for all data sets). *, p < 0.05; **, p < 0.01; ***, p < 0.0001.
