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Brain-to-plasma ratios of vemurafenib after an oral dose of 25 mg/kg in FVB wild-type, Mdr1a/b(−/−), Bcrp1(−/−), and Mdr1a/b(−/−) Bcrp1(−/−) mice. The mice were sacrificed after 1 h (A) and 4 h (B) postdose of vemurafenib, and whole brain and plasma were analyzed by LC-MS/MS. The B/P ratios were significantly higher in Mdr1a/b(−/−)Bcrp1(−/−) mice than the wild-type mice at both 1 and 4 h postdose. ***, p < 0.0001. Data are mean ± S.D. (n = 3–4 for all data points).
