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. 2012 Jun 21;8(6):e1002577. doi: 10.1371/journal.pcbi.1002577

Figure 2. Glucose-Hormone Responses (GHR) of insulin, glucagon and epinephrine and phosphorylation state Inline graphic.

Figure 2

Experimental data from multiple studies based on oral glucose tolerance tests and hypoglycemic, hyperinsulinemic clamp studies and the corresponding fitted GHR curves. Parameters for the GHR curves in Table 1 and experimental data in Dataset S1. (A) Glucagon GHR. Glucagon increases with decreasing blood glucose from a basal concentration of 37.9 pmol/l to a maximal concentration of 190.0 pmol/l with the inflection point at 3.01 mM (B) Epinephrine GHR. Epinephrine increases with decreasing glucose from a basal concentration of 100 pmol/l to a maximal concentration of 6090 pmol/l with the inflection point at 3.1 mM (C) Insulin GHR. Insulin increases with increasing glucose from a basal concentration of 0 pmol/l to a maximal concentration of 818.9 pmol/l with the inflection point at 8.6 mM (D) Resulting phosphorylation state Inline graphic (Equation 5) based on the GHRs for insulin, glucagon and epinephrine decreasing with increasing glucose from phosphorylated to dephosphorylated.