Table A9.
Cumulative Incidence of Death After Relapse/Disease Progression v Death As a First Event for Infants Age ≤ 1 Year by Cause in COG ALL Trials
| Death As a First or Subsequent Event | Cumulative Incidence (%) |
P | |||
|---|---|---|---|---|---|
| 1990-1994 | 1995-1999 | 2000-2005 | Overall | ||
| 5-year | |||||
| Relapse/disease progression or secondary malignancies as first event | 43.03 | 15.89 | 27.21 | 28.92 | < .001 |
| Treatment-related death prior to relapse/disease progression | 3.90 | 27.17 | 13.87 | 14.79 | < .001 |
| Unknown or unrelated | 5.21 | 8.88 | 5.72 | 6.56 | .2774 |
| Overall | 52.14 | 51.94 | 46.80 | 50.27 | .4503 |
| 10-year | |||||
| Relapse/disease progression or secondary malignancies as first event | 43.73 | 15.89 | — | 29.20 | < .001 |
| Treatment-related death prior to relapse/disease progression | 3.90 | 27.17 | — | 14.79 | < .001 |
| Unknown or unrelated | 5.21 | 9.86 | — | 6.95 | .1454 |
| Overall | 52.83 | 52.92 | 50.93 | .6231 | |
Abbreviations: ALL, acute lymphoblastic leukemia; COG, Children's Oncology Group.