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. 2012 May 30;51(25):5125–5141. doi: 10.1021/bi300299z

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Copyright © 2012 American Chemical Society

This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.

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Possible exit gate in the drug binding domain of Pgp. The transmembrane helices of the drug binding domain of Pgp are shown as silver cartoons, while the extramembranous protein is colored black. Alanine 841 (TM9), V715 (TM7), and G722 (TM7) are shown in space-filling representation. A841 is on the right-hand side of each figure, while V715 and G722 are on the left. V715 is above G722. From left to right are shown the fully opened inward, partially opened inward, partially opened outward, and fully opened outward conformations, respectively. A similar figure with color-coded helices for ease of identification of individual structures is presented in Figure S10 of the Supporting Information.