Table 3.
Univariate and Multivariate Cox Proportional Hazards Regression Models of Clinical Factors of RFS
| Factor | Univariate Analysis |
Multivariate Analysis |
||
|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | |
| Response | ||||
| Complete response | 1 | 1 | ||
| Intermediate response | 1.69 | 0.10 to 2.87 | 1.80 | 1.01 to 3.21 |
| Poor response | 3.21 | 1.99 to 5.17 | 3.01 | 1.75 to 5.16 |
| Clinical T classification | ||||
| cT2 | 1 | 1 | ||
| cT3 | 1.32 | 0.65 to 2.70 | 1.11 | 0.54 to 2.29 |
| cT4 | 2.32 | 1.06 to 5.06 | 1.47 | 0.64 to 3.40 |
| Clinical N classification | ||||
| Negative | 1 | 1 | ||
| Positive | 1.27 | 0.96 to 1.70 | 1.48 | 1.08 to 2.01 |
| Sex | ||||
| Male | 1 | 1 | ||
| Female | 0.96 | 0.73 to 1.26 | 0.93 | 0.69 to 1.25 |
| Age, years | ||||
| ≤ 60 | 1 | 1 | ||
| 61–75 | 1.31 | 0.99 to 1.75 | 1.50 | 1.11 to 2.04 |
| > 75 | 2.08 | 1.34 to 3.23 | 2.24 | 1.36 to 3.68 |
| Lymphovascular invasion | ||||
| None | 1 | 1 | ||
| Present | 2.07 | 1.48 to 2.90 | 1.54 | 1.01 to 2.35 |
| Undetermined | 0.80 | 0.56 to 1.12 | 1.07 | 0.59 to 1.94 |
| Perineural invasion | ||||
| None | 1 | 1 | ||
| Present | 2.52 | 1.69 to 3.75 | 1.46 | 0.90 to 2.36 |
| Undetermined | 0.86 | 0.64 to 1.16 | 0.57 | 0.34 to 0.95 |
| Location of tumor, cm from AV | ||||
| > 10 | 1 | 1 | ||
| 6–10 | 1.02 | 0.77 to 1.35 | 1.15 | 0.85 to 1.55 |
| ≤ 5 | 0.70 | 0.36 to 1.38 | 0.87 | 0.42 to 1.82 |
| Tumor grade | ||||
| G1, G2 | 1 | 1 | ||
| G3, G4 | 1.27 | 0.87 to 1.86 | 1.20 | 0.79 to 1.81 |
| Adjuvant chemotherapy | ||||
| No | 1 | 1 | ||
| Yes | 0.63 | 0.46 to 0.86 | 0.56 | 0.38 to 0.82 |
Abbreviations: AV, anal verge; HR, hazard ratio; RFS, recurrence-free survival.