Table 2.
Experiment | Vβ family | Jβ segment | Clonotype name | Nucleotide sequence | Translation |
---|---|---|---|---|---|
1 | 1 | 1.4 | sPGQs.231B1B14L12 | AGCCCCGGACAATCC | CASSPGQSNERLFFG |
4 | 1.1 | sLGTDn.3431B4B11L12 | AGCCTTGGGACAGATAAC | CASSLGTDNTEVFFG | |
6 | 2.12 | sIWGn.214B6B21L12 | AGTATCTGGGGGAAC | CASSIWGNYAEQFFG | |
6 | 2.1 | iGAGEy.4342B6B21L13 | ATAGGGGCAGGGGAGGAGTAT | CASSIGAGEYAEQFFG | |
8.1 | 2.5 | dAREPq.3612B8.1B25L10 | GATGCAAGGGAACCCCAG | CASSDAREPQYFG | |
8.1 | 2.2 | sGRn.45B8.1B22L11 | AGTGGGAGAAAC | CASSGRNTGQLYFG | |
8.1 | 2.6 | sWDRVy.1262B8.1B26L11 | AGTTGGGACAGGGTCTAT | CASSGRNTGQLYFG | |
8.1 | 2.2 | dALGGt.1644B8.1B22L13 | GATGCTCTGGGGGGGACC | CASSDALGGTGQRYFG | |
15 | 1.3 | gASDSs.2225B15B13L11 | GGTGCCTCCGACAGTTCT | CGASDSSGNTLYFG | |
2 | 5.2 | 2.3 | sLEGDt.6242B5.2B11L11 | TCTCTGGAGGGGGACACA | CASSLEGDTEVFFG |
6 | 1.3 | sKTDg.211B6B13L10 | AGCAAGACTGATGGA | CASKTDGNTLYFG | |
6 | 2.1 | iGTGGy.4144B6B21L13 | ATAGGGACTGGGGGGTAT | CASSIGTGGYAEQFFG | |
8.1 | 2.4 | sDGWGq.2214B8.1B24L12 | GACGGCTGGGGGCAA | CASSDGWGQNTLYFG | |
12 | 2.6 | sDWGGy.2144B12B26L11 | AGTGACTGGGGGGGGTAT | CASSDWGGYEQYFG | |
12 | 2.1 | lTGQy.232B12B21L12 | TTAACCGGACAGTAT | CASSOTGQYAEQFFG | |
3 | 1 | 1.1 | qEGGn.141B1B11L12 | CAAGAAGGGGGTAAC | CASSQEGGNTEVFFG |
8.1 | 2.6 | dAGNy.441B8.1B26L11 | GATGCGGGGAATTAT | CASSDAGNYEQYFG | |
8.1 | 2.5 | sAGGAd.1442B8.1B25L11 | AGTGCTGGGGGGGCCGAC | CASSAGGADTQYFG | |
8.1 | 2.2 | sPGQGDt.43242B8.1B22L13 | AGTCCGGGACAGGGGGACACC | CASSPGQGDTGQLYFG | |
10 | 1.3 | sLTDSGDt.231131B10B13L12 | AGCTTGACAGATTCTGGAGATAC | CASSLTDSGDTLYFG | |
10 | 2.1 | sSTWGn.4212B10B21L13 | AGCTCGACCTGGGGCAAC | CASSSTWGNYAEQFFG | |
15 | 1.5 | aATGDq.4342B15B15L10 | GCTGCGACAGGGGACCAG | CGAATGDQAPLFG | |
15 | 2.6 | rESs.26B15B26L10 | AGGGAGAGCTCC | CGARESSYEQYFG | |
15 | 2.4 | rSs.5B15B24L10 | AGGAGTAGT | CGARSSQNTLYFG | |
15 | 1.4 | rDTGe.112B15B14L10 | AGGGATACTGGCGAA | CGARDTGERLFFG | |
15 | 2.6 | aSLGGPy.66432B15B26L11 | GCTAGCCTGGGGGGCCCCTAT | CGASLGGPYEQYFG |
Amino acid and nucleotide sequences of high-frequency clonotypes that were obtained from the colons of mice with pathologic evidence of colitis. Data are derived from 3 independent experiments in which mice received either unseparated spleen cells adjusted to yield a fixed αβ T-cell dose (experiments 1 and 2 in Table 1) or purified CD4+ T cells (experiment 3 in Table 1). Nucleotide sequences in bold correspond to the bold amino acid sequence. Clonotypes were defined using the nomenclature described in Yassai et al.27