Tab. 1.
Solubility, pKa, MW, log P and structural change of selected acidic drugs.
| Drugs | -CH-COOH X | Log P [11] O/W | Log P CH/W | MW | pKa [10] | Solubility water 25°C (mg/mL) |
|---|---|---|---|---|---|---|
| Diclofenac (D) | -H | 4.40 | 2.09 | 296.20 | 4.5 | 6.00 10−3 [6] |
| Flurbiprofen (F) | -CH3 | 4.24 | 1.87 | 244.26 | 4.2 | 2.70 10−2 * |
| Indomethacin (I) | -H | 4.27 | 0.82 | 357.81 | 4.5 | 4.00 10−3 [7] |
| Ketoprofen (K) | -CH3 | 3.12 | 1.48 | 254.29 | 4.8 | 1.69 10−1 [8] |
| Naproxen (N) | -CH3 | 3.34 | 0.89 | 230.26 | 4.2 | 3.10 10−2 [9] |
*
The solubility of Flurbiprofen was determined experimentally.