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. 2012 Jun 12;5(2):313–319. doi: 10.1159/000339611

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Copyright © 2012 by S. Karger AG, Basel

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.

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Fig. 2 — Microscopic appearance of the MANEC tumour. a Moderately differentiated adenocarcinoma intimately admixed with a poorly differentiated neuroendocrine carcinoma. HE ×10. b Squamous cell carcinoma component admixed with the NEC component. Squamous ×10. c Positivity of the neuroendocrine component for chromogranin and negativity of the adenocarcinomatous component for chromogranin. Chromogranin ×20. d Negativity of the squamous cell carcinoma for chromogranin and positivity of the NEC for chromogranin. Chromo-squamous ×20. e Squamous cell differentiation as confirmed by the positivity for high molecular weight cytokeratins such as CK5. CK5-squamous ×20. f Negativity of both the adenocarcinomatous component and the NEC component for CK5. CK5-adeno-NEC.