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. 2012 May 2;22(3):297–303. doi: 10.1016/j.sbi.2012.03.011

Figure 2.

Figure 2

Structural basis for dsRNA recognition and activation of RLRs. (a) C-terminal RNA binding domain in the presence of RNA (PDB: 3NCU). (b) Helicase domain in the presence of RNA (PDB: 4A36). (c) In the autoinhibited conformation, the N-terminal CARDs are sequestered from signaling and the pincer maintains RIG-I in an autoinhibited state (PDB: 4A2W). Binding of dsRNA to the CTD brings HEL2i in contact with dsRNA (PDB: 2YKG). The change in conformation upon dsRNA binding presumably releases the CARD domains for signaling.