Table 1.

Summary of RLR structural studies

RLRa	Domainsb	ATPc	RNA	PDB	Reference
hRIG-I	T			2QFB, 2QFD	[34]
hRIG-I	T			2RMJ	[33•]
hMDA-5	T			3GA3
hLGP2	T			2W4R	[43]
hLGP2	T		5′ OH dsRNA (8 mer)	3EQT	[18]
hLGP2	T			2RQA	[20]
hMDA-5	T			2RQB	[20]
hRIG-I	T		5′ppp dsRNA (12 mer)	3NCU	[16•]
hRIG-I	T		5′ppp dsRNA (14 mer)	3LRN	[15•]
hRIG-I	T		5′ppp dsRNA (12 mer)	3LRR	[15•]
hRIG-I	T		5′OH dsRNA (14 mer)	3OG8	[19]
dRIG-I	T			4A2V	[13••]
dRIG-I	T		5′OH dsRNA (14 mer)	4A2X	[13••]
dRIG-I	H	Analog	5′OH dsRNA (19 mer)	4A36	[13••]
dRIG-I	H			4A2P	[13••]
mRIG-I	H	Analog		3TBK	[11••]
hMDA5	HEL2i			3TS9	[39•]
hRIG-I	H, T	Analog	5′ppp dsRNA (14 mer)	3TMI	[12••]
hRIG-I	H, T		5′OH dsRNA (10 mer)	2YKG	[14••]
dRIG-I	C, H			4A2Q	[13••]
dRIG-I	C, H, T			4A2 W	[13••]

^ahuman (h), mouse (m), duck (d).

^bCARDS (C), Helicase (H), Helicase2 insert (HEL2i), C-terminal domain (T).

^cATP or analog.