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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Mol Cell Neurosci. 2012 Apr 26;50(2):193–200. doi: 10.1016/j.mcn.2012.04.007

Figure 4. Synaptic specialization on BDA+ fibers.

Figure 4

Photomicrographs of transverse sections of deafferented cervical spinal cord from PyX wild type (A - D) and PlexinA2-/- (E - L). BDA+ CST fibers can be seen arborizing into deafferented spinal grey matter at low (A, E and I) and high power (B, F and J). Synaptophysin-immunoreactive puncta can be seen colocalizing with BDA+ CST axons in both wild type (C and D) and PlexinA2-/- (G and H, K and L) mice. BDA+ CST axons in PlexinA2-/- mice demonstrate puncta of colocalization with pre- and post-synaptic specializations (white arrows O and P) detected with the SV2 (M, O and P) and PSD-95 (N, O and P), respectively. Scale bar A = 50 μm, B and M = 10 μm.