Figure 4.
Superresolution images of RNA polymerase (β′-yGFP) within K-12 cells grown in EZRDM at 30°C. (A) Four representative cells. (B) Expanded view of a medium-length cell (tip-to-tip length = 3.9 μm). (C) Expanded view of a long cell (tip-to-tip length = 5.2 μm). (D) Relative number of RNAP copies at each axial position x (100 nm bins). Solid line is the result of a Savitzky-Golay smoothing filter. The grey background shows the theoretical profile for a uniform distribution filling the model spherocylinder, as in Fig. 3. Note that RNAP avoids the endcaps.