Table 4.

Clinical chemistry parameters from female C57Bl/6 mice at day 13 and day 28 of toxicity analysis

Treatment	Alk phos (U/L)	ALT (U/L)	AST (U/L)	BUN (mg/dL)	Creatinine (mg/dL)
Day 13
Control	117 ± 10	58 ± 17	69 ± 8	18 ± 2	a
Cisplatin	113 ± 16	a	115 ± 24b	75 ± 21b	a
Cisplatin/cl-micelles	111 ± 27	43 ± 9	81 ± 12c	22 ± 4c	a
Empty cl-micelles	128 ± 20	50 ± 9	59 ± 7c	18 ± 2c	a
Day 28
Control	136 ± 12	85 ± 28	d	20 ± 0	0.32 ± 0.05
Cisplatin	131 ± 12	112 ± 45	d	43 ± 6b	0.38 ± 0.03b
Cisplatin/cl-micelles	128 ± 25	93 ± 20	d	21 ± 5	0.29 ± 0.03
Empty cl-micelles	143 ± 15	100 ± 43	d	23 ± 5	0.34 ± 0.06

Notes: P values less than 0.05 were set as the level of significance. Data were expressed as mean ± standard deviation.

^aThese parameters could not be estimated due to inadequate blood draw.

^bRepresents significant difference from controls.

^cRepresents significant difference from free cisplatin.

^dThese parameters could not be accurately measured due to hemolysis in samples at blood draw.

Abbreviations: Alk phos, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen.