Table 4.
Berry polyphenol interaction with growth factor receptor signaling and its downstream effects
| Polyphenol | GFR type | Cell line | Dose | Effect observed | Reference |
|---|---|---|---|---|---|
| Cyanidin | EGFR | A431 (Human vulva carcinoma) | 0.8 μM | ↓ tyrosine kinase activity ↓ phosphorylation of ELK-1 and MAPK-1 |
(38) |
| HER2 | MDA-MB231 BT474 MCF-7ErbB2 (ethanol mediated) |
10–40 μM | ↓ cell migration ↓ autophosphorylation ↓ phosphorylation of FAK and p130cas ↓ association of FAK and p130cas to ErbB2 |
(141) | |
| Delphinidin | EGFR | AU565 MCF-10 A |
40 μM | ↓ autophosphorylation ↓ phosphorylation of AKT, ERK1/2, JNK1/2/P38 |
(142) |
| A431 | 1.3 μM | ↓ tyrosine kinase activity | (38) | ||
| HER2 | SKBR3 | 12.5–100 μM | ↓ autophosphorylation ↓ phosporylation of ERK1/2 ≫ AKT |
(41) | |
| Quercetin | EGFR | HT29 (Colon carcinoma) | 0.5–10μM | ↓ autophosphorylation ↓ phosphorylation of ERK1/2 |
(143) |
| HER2 | SKBR3 MCF7 |
100–200 μM | ↓ tyrosine kinase activity ↑ ubiquitination ↓ expression ↓ phosphorylation of PI3K and AKT |
(144) | |
| Ellagic Acid | EGFR | HT29 | 65nM 100 μM |
↓ tyrosine kinase activity ↔ autophosphorylation ↓ cell growth |
(37) |
| Resveratrol | EGFR | MDA-MB-231 | 50 μM | ↓ phosphorylation of FAK ↓ cell migration and invasion |
(145) |
| HER2 | MCF7 (Heregulin B1 induced) | 2–10μM | ↔ autophosphorylation ↓ phosphorylation of ERK1/2 ↓ ERK-mediated MMP9 activation |
(146) | |
| Pterostilbene | HER2/3 | MCF7 (Heregulin B1 induced) | 5–20 μM | ↓ phosphorylation of AKT and p38 ↓ MMP-9 ↔ phosphorylation of ERK1/2 |
(147) |
| Procyanidins | EGFR | HT29 | 5–50 μM | ↓ tyrosine kinase activity ↓ autpphosphorylation |
(148) |
Abbreviations: ELK-1- E twenty-six (ETS)-like transcription factor 1; MAPK-1- Mitogen activated protein kinase 1; FAK- focal adhesion kinase; p130cas- Crk-associated protein; ERK- extracellular signal regulated kinase; JNK- c-Jun N-terminal kinase; PI3K- phosphatydylinositol-3-phosphate kinase; MMP- matrix metalloproteinase.