TABLE 6.
Genes that were significantly different in the ANOVAs of the 5 line-pairs and were significantly changed in the same direction in at least 3 line-pairs
| Symbol | Description | Higher or lower in 3 or 4 line-pairsa | H1b | H2 | P | AA | sP |
|---|---|---|---|---|---|---|---|
| Ankrd12 | Ankyrin repeat domain 12 | Higher | X | X | X | X | |
| Crebl2 | cAMP responsive element binding protein-like 2 | Lower | X | X | X | ||
| Fam102b | Family with sequence similarity 102, member B | Lower | X | X | X | ||
| Fam40a | Family with sequence similarity 40, member A | Higher | X | X | X | ||
| Gsta4 | Glutathione S-transferase alpha 4 | Lower | X | X | X | X | |
| H1f0 | H1 histone family, member 0 | Higher | X | X | X | ||
| Itga9 | Integrin alpha 9 | Lower | X | X | X | ||
| Itgb2 | Integrin beta 2 | Lower | X | X | X | ||
| Mx2 | Myxovirus resistance 2 | Higher | X | X | X | ||
| Ncaph | Non-SMC condensing l complex, subunit H | Higher | X | X | X | X | |
| Pls1 | Plastin 1 | Lower | X | X | X | ||
| Psd3 | Pleckstrin & Sec7 domain containing 3 | Lower | X | X | X | X | |
| Rac1 | Ras-related C3 botulinum toxin substrate 1 | Higher | X | X | X | ||
| Rock2 | Rho-associated coiled-coil containing protein-kinase 2 | Lower | X | X | X | ||
| RT1-A2 | RT1 classIa, locus A2 | Higher | X | X | X | ||
| RT1-T24-4 | RT1 class I, locus T24, gene 4 | Higher | X | X | X | X | |
| RT1-DMb | RT1 claaa II, locus DMb | Lower | X | X | X | X | |
| Scpep1 | Serine carboxypeptidase 1 | Lower | X | X | X | ||
| Slc38a10 | Solute carrier family 38, member 10 | Lower | X | X | X | X | |
| Smtnl2 | Smoothelin-like 2 | Lower | X | X | X | ||
| Zfp212 | Zinc finger protein 212 | Lower | X | X | X | X | |
| Znf23 | Zinc finger protein 23 | Higher | X | X | X |
To qualify for this list, the gene needed to be significantly different in the overall analysis and (a) be significantly different in 4 of the line-pairs and have the same direction of change in all 4 line-pairs, or (b) be significantly different in 3 of the line- pairs, have the same direction of change in the 3 line-pairs, not have a significant change in the opposite direction in more than 1 of the remaining 2 line-pairs, and be listed in at least one network identified by Ingenuity Pathway Analysis. ‘Higher’ (or ‘lower’) indicates values were higher (or lower) in the high ethanol consuming rats compared to the low ethanol consuming rats.
Indicates which line-pair was significantly different; H1 = HAD1-LAD1; H2 = HAD2-LAD2; P = P-NP; AA = AA-ANA; sP = sP-sNP