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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2011 Dec 8;1819(9-10):1080–1087. doi: 10.1016/j.bbagrm.2011.11.008

Figure 3. mtDNA and TFAM function in an interdependent manner.

Figure 3

Upper panel, Upon mtDNA depletion, TFAM is degraded by the Lon protease; middle panel, mtDNA and TFAM stabilize each other; lower panel, reduction of TFAM results in depletion of mtDNA.