Skip to main content
. Author manuscript; available in PMC: 2013 Aug 16.
Published in final edited form as: Neuroscience. 2012 Apr 30;217:56–66. doi: 10.1016/j.neuroscience.2012.04.054

Figure 4. Disruption of Kv2.1 clustering by the soluble C-terminus of Kv2.2 has no effect on Kv2.1 channel modulation by NMDAR activation.

Figure 4

A. Representative whole-cell currents from HEK293 cells expressing full-length GFP-Kv2.1 + Kv2.2CT plus NMDAR, either before (- glut) or at the indicated time following addition of 10 μM glutamate. B. Average normalized I-V relationship illustrating that even in the presence of Kv2.2CT, NMDAR activation induces a hyperpolarizing shift in the voltage-dependence of activation of Kv2.1. The average V1/2 for all conditions is presented in panel C. D. Whole-cell K+ currents from a representative rHN transfected with Kv2.2CT before (left) and 10 minutes after the addition of 10 μM glutamate+50 μM glycine (right). E. Average normalized G-V relationship for all neurons before (closed symbols) and after (open symbols) glutamate addition.