Table 5.
Change in CD4 counts (cells per μL) during tuberculosis (TB) treatment in 633 HIV positive pulmonary TB patients by timing of antiretroviral treatment (ART) in relation to start of TB treatment 1
| Not on ART (n = 410) | ART at baseline (n = 80) | ART 0-2 months (n = 87) | ART 2-5 months (n = 55) | P | |
|---|---|---|---|---|---|
| Baseline2 (n = 632) | 315 (293; 336)[410]a | 262 (223; 300)[80] | 196 (167; 225)[87]a | 238(197;279)[55]a | < 0.001 |
| 2 months (n = 546) |
361 (333; 389)[348]a | 299 (253; 345)[72] | 261 (216; 306)[72]a | 283 (231;335)[55] | 0.002 |
| Change | 40 (10; 70)[348] | 41 (-13; 96)[72] | 60 (14; 106)[72] | 44 (-10; 99)[55] | 0.95 |
| 5 months (n = 500) |
314 (289; 339)[317] | 286 (248; 323)[64] | 268 (217; 319)[67] | 344 (282;405)[52] | 0.20 |
| Change | -11 (-42; 20)[317]a | 20 (-31; 70)[64] | 69 (22; 117)[67] | 110 (52; 168)[52]a | 0.004 |
1 Data are mean (95% confidence interval). Where p-values are found significant, means with different suprascripts are significantly different. Pulmonary TB status was based on culture, except where culture data were not available, in which cases microscopy results were used.