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Proportion of patients meeting the two-measure and three-measure composite responder criteria at 3 months, observed cases. From Study 1 [Mease et al. 2009b], Study 2 [Clauw ef at. 2008a], Study 3 [Arnold et al. 2009a], and Study 4 [Branco ef at. 2010]. *p < 0.05; **p < 0.01; ***p ≤ 0.001 versus placebo.
