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Least squares mean changes from baseline in Multidimensional Fatigue Inventory total scores. From pooled analysis (N=2084) of Studies 1 and 2 [Clauw et al. 2008b], mixed-effects model repeated measures. Visits correspond to 3 weeks (Visit 1), 7 weeks (Visit 2), 11 weeks (Visit 3), and 15 weeks (Visit 4) of double-blind treatment (including 3 weeks of dose escalation and 12 weeks of stable dose treatment). *p < 0.05; **p ≤ 0.01; ***p < 0.001 versus placebo.
