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Least squares mean changes from baseline in Multiple Ability Self-Report Questionnaire total scores. From pooled analysis (A/=3109) of Studies 1, 2, and 3 [Manevitz et al. 2009], mixed-effects model repeated measures. Visits correspond to 0 weeks (Visit 1), 4 weeks (Visit 2), 8 weeks (Visit 3), and 12 weeks (Visit 4) of double-blind stable dose treatment. *p < 0.05; **p≤ 0.01; ***p ≤ 0.001 versus placebo.
