Table 3.
Oxidative stress and inflammatory markers in osteoarthritis subjects before and after vitamin E supplementation (mean ± SD).
| Subject number | Particulars | Group I (n = 40) | Group II (n = 40) | Percentage increase | Percentage decrease |
|---|---|---|---|---|---|
| 1 | SOD level (U/gm Hb) | 1064.75 ± 20.03 | 1305.95** ± 18.05 | 22.5 | — |
| 2 | Ceruloplasmin (mg%) | 30.57 ± 1.02 | 33.8 ± 1.48* | — | 10.6 |
| 3 | GSHPx (IU/gm Hb) | 20.59 ± 1.36 | 24.6 ± 1.08** | 20.8 | — |
| 4 | Catalase (KU/L) | 21.87 ± 1.62 | 27.05 ± 1.50** | 23.7 | — |
| 5 | Malondialdehyde (µmol MDA/ml) | 3.81 ± 0.21 | 2.83 ± 0.19** | — | 24.5 |
| 6 | CRP (mg/L) | 5.32 (0.14) | 4.85 (0.12)* | — | 8.83 |
| 7 | IL-6 (pg/ml) | 73.0 (4.9) | 61.2 (2.8)* | — | 16.2 |
*
p < 0.05, significant; **p < 0.001, highly significant.
SOD, superoxide dismutase; GSHPx, glutathione peroxidase; CRP, plasma C- reactive protein; IL-6, synovial interleukin 6.