Figure 1. Schematic view of the epigenetic dynamics at induced genes during early T-cell differentiation. In the early CD4^-CD8^- double negative (DN) thymocytes, the enhancer is enriched for H3K4me1 and is found in a poised configuration. During differentiation into CD4⁺CD8⁺ double positive (DP) thymocytes, induced enhancers recruit Pol II and acquire H3K4me3. The profiles shown here are inspired of canonical loci described in reference ¹⁸.