. Author manuscript; available in PMC: 2013 May 1.

Published in final edited form as: J Thorac Oncol. 2012 May;7(5):833–840. doi: 10.1097/JTO.0b013e31824de09c

Table 2.

Frequency of membrane transporters and thymidylate synthase (TS) immmunohistochemical expression in NSCLC by tumor histology

Marker	Any Expression (Score > 0)			Average Score
Marker	Adenocarcinoma Positive/Total (%)	SCC^¥ Positive/Total (%)	P Value^*	Adenocarcinoma Score (SD)	SCC^¥ Score (SD)	P Value^†
FRα
Cytoplasm	152/174 (87%)	63/110 (57%)	< 0.001	91.6 (66.4)	35.9 (40.3)	< 0.001
Membrane	107/174 (61%)	29/110 (26%)	< 0.001	72.2 (89.0)	11.29 (28.8)	< 0.001
RFC1
Cytoplasm	181/182 (99%)	110/112 (98%)	0.56	162.7 (83.2)	153.2 (72.0)	0.34
Membrane	164/182 (90%)	103/112 (92%)	0.68	128.1 (95.9)	119.2 (86.1)	0.59
TS
Cytoplasm	130/165 (79%)	82/102 (80%)	0.75	52.2 (40.1)	55.6 (42.0)	0.565
Nuclear	58/165 (35%)	59/102 (58%)	0.0003	9.3 (21.1)	13.8 (27.7)	0.0043

^¥

SCC = Squamous cell carcinoma

Fisher’s exact test

^†

Wilcoxon rank-sum test