Table 5.
Immune mediators by pregnancy status at return visit 1 (n=23)*
| Median (Range) | ||||
|---|---|---|---|---|
| Pregnant (n=15) | Non-pregnant (n=8) | P1 | P2 | |
| Gestational age in weeks | 34 (28-38) | -- | -- | -- |
| RANTES | ||||
| (pg/ml) | 6.0 (4.2-47.2) | 5.1 (4.2-28.3) | 0.2 | 0.1 |
| (pg/10μg protein) | 0.9 (0.1-2.1) | 3.1 (1.3-42.3) | 0.004 | 0.01 |
| Eotaxin | ||||
| (pg/ml) | 20.9 (0-133.6) | 17.1 (0-48.9) | 0.4 | 0.3 |
| (pg/10μg protein) | 2.9 (0-12.6) | 6.0 (0-41.1) | 0.04 | 0.1 |
| Fractalkine | ||||
| (pg/ml) | 44.2 (0-625.2) | 44.2 (0-360.4) | 0.8 | 0.2 |
| (pg/10μg protein) | 9.0 (0-22.5) | 37.1 (0-451.4) | 0.02 | 0.1 |
| G-CSF | ||||
| (pg/ml) | 8.5 (0-14202.9) | 6.7 (3.5-54.2) | 0.1 | 0.3 |
| (pg/10μg protein) | 1.2 (0-205.3) | 4.5 (1.1-67.9) | 0.08 | 0.5 |
| IL-1α | ||||
| (pg/ml) | 49.1 (5.9-2193.1) | 6.9 (2.7-41.3) | 0.01 | 0.01 |
| (pg/10μg protein) | 2.7 (0.7-31.7) | 4.3 (0.7-33.8) | 0.7 | 0.3 |
| IL-1RA | ||||
| (pg/ml) | 40898.3 (408.4-85612.1) | 442.7 (0-14440.9) | 0.002 | 0.01 |
| (pg/10μg protein) | 3012.9 (161.5-7003.0) | 272 (0-5929.3) | 0.01 | 0.01 |
| IL-6 | ||||
| (pg/ml) | 4.5 (2.9-70.8) | 4.2 (3.5-29.9) | 0.5 | 0.3 |
| (pg/10μg protein) | 0.8 (0.1-2.2) | 3.3 (1.2-40.8) | 0.006 | 0.04 |
| IL-8 | ||||
| (pg/ml) | 118.0 (0-4100.3) | 25.8 (0-778.1) | 0.1 | 0.4 |
| (pg/10μg protein) | 11.4 (0-281.9) | 13.7 (0-104.3) | 0.8 | 0.7 |
| IP-10 | ||||
| (pg/ml) | 165.0 (0-2141.8) | 0 (0-144.3) | 0.06 | 0.01 |
| (pg/10μg protein) | 8.0 (0-82.9) | 0 (0-19.4) | 0.1 | 0.09 |
| MCP-1 | ||||
| (pg/ml) | 7.6 (2.8-103.0) | 6.5 (4.2-20.9) | 0.7 | 0.7 |
| (pg/10μg protein) | 0.8 (0.1-2.7) | 3.3 (1.3-42.4) | 0.006 | 0.008 |
| MIP-1α | ||||
| (pg/ml) | 30.2 (0-103.5) | 21.1 (0-66.6) | 0.2 | 0.2 |
| (pg/10μg protein) | 3.9 (0-17.3) | 8.7 (0-77.3) | 0.09 | 0.3 |
| MIP-1β | ||||
| (pg/ml) | 13.6 (0-267.8) | 10.5 (0-103.3) | 0.4 | 0.09 |
| (pg/10μg protein) | 2.4 (0.1-7.7) | 7.7 (0-13.8) | 0.2 | 0.6 |
| TNF-α | ||||
| (pg/ml) | 0 (0-59.9) | 0 (0-23.2) | 1.0 | 0.2 |
| (pg/10μg protein) | 0 (0-1.6) | 0 (0-3.1) | 0.8 | 0.8 |
| GM-CSF | ||||
| (pg/ml) | 1.2 (0-27.6) | 0 (0-5.6) | 0.2 | 0.04 |
| (pg/10μg protein) | 0.2 (0-1.0) | 0 (0-0.8) | 0.5 | 0.06 |
| Elafin | ||||
| (pg/ml) | 29390 (12270-81700) | 28405 (18240-54900) | 0.5 | 0.6 |
| (pg/10μg protein) | 3025.2 (186.9-12345.1) | 15375 (4184.5-186122.4) | 0.02 | 0.04 |
| SLPI | ||||
| (pg/ml) | 31616 (0-68672) | 22759 (6586-98452) | 1.0 | 0.5 |
| (pg/10μg protein) | 2551.5 (0-21898.6) | 11764.9 (2069.4-146571.4) | 0.02 | 0.1 |
| HBD2 | ||||
| (pg/ml) | 900 (10-8740) | 640 (80-5140) | 0.8 | 0.8 |
| (pg/10μg protein) | 36.8 (3.5-1239.4) | 451 (69.5-2110.4) | 0.03 | 0.004 |
| MIP-3α | ||||
| (pg/ml) | 4 (4-104) | 16 (4-5140) | 0.1 | 0.2 |
| (pg/10μg protein) | 1.6 (0.1-15.3) | 16.3 (1.1-2110.4) | 0.01 | 0.04 |
1
P-value by Wilcoxon rank-sum test for difference between groups.
2
P-value by van Elteren test for difference between groups, adjusting for overweight BMI & White race.
RANTES: Regulated on Activation, Normal T Expressed and Secreted; G-CSF: granulocyte-colony stimulating factor; IL: interleukin; RA: receptor antagonist; IP: interferon-inducible protein; MCP: monocyte chemoattractant protein; TNF: tumor necrosis factor; GM: granulocyte macrophage; SLPI: Secretory leukocyte protease inhibitor; HBD: human beta defensin; MIP: macrophage inflammatory protein