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. Author manuscript; available in PMC: 2013 Jun 21.
Published in final edited form as: Neuron. 2012 Jun 21;74(6):1005–1014. doi: 10.1016/j.neuron.2012.04.026

Figure 3. Heteromeric channels formed by TREK1-PCS and WT retain normal regulation by external acidification.

Figure 3

(A) Representative example of the effect of acidic pH on the light-gated current of TREK1-PCS/WT. Alternating illumination at 500 nm (green) and 380 nm (magenta) reversibly blocks and unblocks, respectively, the constant outward current, both at pH7.4 and pH6.5, but the amplitude of the photo-modulation is smaller at pH6.5. (B) Inhibition by external acidification from pH7.4 to pH 6.5 of the photo-blocked current component of TREK1-PCS/WT heteromeric channels is similar to the inhibition of total WT current under the same condition. Numbers in parentheses above bars indicate number of cells tested.