Figure 6. C3aR antagonism improves neurological function following reperfused stroke.

The Morris water maze was used to evaluate navigational memory at 7 days post-stroke. Significant improvement (vehicle: n = 21, acute: n = 24, combined: n = 23, delayed: n = 23) was observed in both acutely and combined-treated mice (p = 0.04* and p = 0.002** respectively) (A). The corner turn test was employed to evaluate post-ischemic sensorimotor function and demonstrated significantly (p = 0.02) improved outcome in the acutely-treated animals (vehicle: n = 25, acute: n = 26, combined: n = 24, delayed: n = 28) (B).