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. 2012 Jun 26;7(6):e39696. doi: 10.1371/journal.pone.0039696

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Yang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Timeline of effects of SSZ on locomotor activity. Locomotor activity was tested 20 min (Post-T) and 24 h (Re-T) after SSZ administration (10 mM) for 5 min. (B) Sulfasalazine (10 mM) did not affect locomotor activity 20 min or 24 h after infusion. (C) Timeline of SSZ-induced conditioned place preference/aversive procedure. A double 2-day-session training procedure was used to test the aversive or rewarding effects of SSZ. (D) Sulfasalazine did not induce any aversion to or preference for the drug-paired chamber (CPA score), indicating that SSZ had no aversive or rewarding effects. The data are expressed as mean ± SEM. Pre-T, pre-treatment; Post-T, post-treatment; Re-T, re-test.