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. 2012 Jun 26;10(6):e1001350. doi: 10.1371/journal.pbio.1001350

Figure 3. Epac2 is required for selective maintenance of basal dendrite complexity and length.

Figure 3

(A) Binary images of cultured cortical neurons (DIV 23–28) expressing GFP, GFP+Epac2-RNAi, or GFP+Epac2-RNAi+Epac2-rescue. (B) Epac2-RNAi selectively reduces complexity of basal arbors. Expression of RNAi-insensitive Epac2-rescue recovers Epac2-RNAi-induced reduction of basal dendrite complexity to control levels. (C) Epac2-RNAi reduces basal dendritic length, while Epac2-rescue prevents this effect. ‡, difference between Epac2-rescue and Epac2-RNAi, p<0.05, *p<0.05, **p<0.01, ***p<0.001; scale bars, 100 µm.