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. 2012 Jun 26;7(6):e39069. doi: 10.1371/journal.pone.0039069

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Wei et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Tube formation of EPCs treated by supernatants of spheroid cells was higher than their counterparts. And tube formation of EPCs was suppressed when we block the function of VEGF by bevacizumab. (B) The VEGF concentrations in supernatants of spheroid cells were higher than those of adherent cells. (C) Higher VEGF expression was observed in the spheroid cells compared with their counterparts.