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. 2012 Jun 26;7(6):e39069. doi: 10.1371/journal.pone.0039069

Figure 7. Spheroid cells possess higher tumorigenic and metastatic potential in vivo and EPCs can increase these capacities.

Figure 7

(A–F) The spheroid cells showed significantly higher tumorigenecity than adherent cells (A, B, E). And the volumes of subcutaneous tumors in spheroid cells plus EPCs groups were larger than those of spheroid cells groups (C, D, F). (G–J) Microvessel density (MVD) of tumor developed by HCT116 spheroid cells (H) was higher than that of HCT116 (G). The highest MVD among these groups was found in tumor tissue developed from HCT116 sphere plus 1/10 EPCs (I, J). And more blood vessel developed from human EPCs in HCT116 sphere plus EPCs group (L) were found than that of pure spheroid cells group (K). (M) The HCT116 spheroid cells developed more liver metastatic foci than HCT116.